drug-drug interactions — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1199	Mitotane	Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD	Apoptosis , AChR
	Mitotane (NCI-C04933) is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors a...		Apoptosis , AChR
T3797	Isosilybin	Isosilybinin,Isosilibinin,Silymarin,Silybin B,Q-100795	P450
	Isosilybin (Isosilibinin) and Silybin might be suitable candidates to design potent PXR antagonists to prevent drug-drug interactions via CYP3A4 in cancer patients.		P450
T5567	Tetradecanedioic acid	Tetradecanedicarboxylate	Others , Endogenous Metabolite
	Tetradecanedioic acid (Tetradecanedicarboxylate) is a long-chain fatty acid that is a type of endogenous metabolite. It can serve as a candidate biomarker for drug-drug interactions mediated by organic anion transporting...		Others , Endogenous Metabolite
T2534	Pitavastatin calcium	P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104	Apoptosis , Mitophagy , Endogenous Metabolite , HMG-CoA Reductase , Autophagy
	Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cyt...
T5S2361	Epiberberine		ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE
	1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte diffe...		ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE
T35841	5-Benzyloxygramine		Dopamine Receptor , 5-HT Receptor
	5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1]. 5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic inter...		Dopamine Receptor , 5-HT Receptor
T68846	Coproporphyrin I dihydrochloride
	Coproporphyrin I dihydrochloride is an appropriate clinical biomarker to recapitulate drug-drug interactions mediated by OATP inhibition.
T37307	Nordoxepin hydrochloride
	Doxepin is a tricyclic antidepressant. Desmethyldoxepin is the primary metabolite of doxepin, produced by metabolism at the liver. The metabolism of tricyclic antidepressants, including doxepin, is affected by a variety ...
T61515	5-HT7 receptor ligand 1
	5-HT7 receptor ligand 1 (Compound 5c) is a potent ligand for the 5-HT7 receptor, with a K i value of 8 nM. The compound demonstrates non-hepatotoxic properties and displays moderate potential for drug-drug interactions w...
T70391	AMG151 HCl
	ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM). ARRY-403 has many favorable physicochemical characteristics an...
T62610	LY3154885
	LY3154885 is an orally active dopamine D1 receptor orthosteric modulator (PAM) that reduces the risk of drug-drug interactions (DDI).
T37788	Resorufin benzyl ether
	Resorufin benzyl ether is a fluorometric probe that acts as a substrate for cytochrome P450 (CYP)3A4. It is typically used near its apparent Km value of 30 μM to screen the inhibition/activation potential of test compoun...
T39700	Ga(III) protoporphyrin IX
	Ga(III)protoporphyrin-IX, a model for interporphyrin interactions in malaria pigment, possesses potent antibacterial effects against gram-negative, gram-positive, and acid-fast bacteria. It exhibits high solubility in me...
T37810	6',7'-Epoxybergamottin
	6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, a...
T35919	N-hydroxy Riluzole
	N-hydroxy Riluzole is a metabolite of the antiglutamatergic agent riluzole .1It is formed from riluzole predominantly by the cytochrome P450 (CYP) isoform CYP1A2 in human hepatic microsomes. 1.Sanderink, G.J., Bournique,...
T36662	Imidafenacin Metabolite M4	Imidafenacin Metabolite M4
	Imidafenacin metabolite M4 is a metabolite of the muscarinic acetylcholine receptor antagonist imidafenacin.1It is formed from imidafenacin by the cytochrome P450 (CYP) isoform CYP3A4. 1.Kanayama, N., Kanari, C., Masuda,...
T36794	Dolutegravir O-β-D-Glucuronide
	Dolutegravir O-β-D-glucuronide is a metabolite of the HIV integrase inhibitor dolutegravir .1It is formed from dolutegravir primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A1in vivobut is also metabolized ...